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KMID : 0365819710110010039
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Journal of Pusan Medical College
1971 Volume.11 No. 1 p.39 ~ p.51
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Effects of Adrenergic Agents and Adrenergic Blocking Agents on the Phosphorylase Activity of Rat Liver
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Abstract
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The author studied the effects of adrenergic agents and adrenergic blocking agents on the phosphorylase activity of rat liver in vivo and in vitro. Especially, the relative ability of adrenergic blocking agents to prevent the liver phosphorylase activation by adrenergic agents was investigated.
The results were as follows;
1) The liver phosphorylase activity was increased by the administration of adrenergic agents such as epinephrine, norepinephrine, isoproterenol and quinterenol in vivo and in vitro in the following order:
Epinephrine>norepinephrine>isoproterenol>quinterenol.
2) The liver phosphorylase activity was slightly increased by adrenergic ?-blocking agents such as phenoxybenzamine and ergotamine, but slightly decreased by adreriergic ?-blocking agent such as propranolol.
3) The liver phosphorylase activation by Epinephrine, norepinephrine, isoproterenol and quinterenol was
completely blocked by ergotamine, but not blocked by propranolol and phenoxybienzamine in Vivo.
4) The liver phosphorylase activation by epinephrine, norepineprine, isoproterenol, quinterenol was
blocked by ergotamine and phenoxybenzamine, but not blocked by propranolol in vitro.
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